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Isabel Espejo Luciano Di Croce Sergi Aranda 《BioEssays : news and reviews in molecular, cellular and developmental biology》2020,42(12):2000203
Chromatin-bound proteins underlie several fundamental cellular functions, such as control of gene expression and the faithful transmission of genetic and epigenetic information. Components of the chromatin proteome (the “chromatome”) are essential in human life, and mutations in chromatin-bound proteins are frequently drivers of human diseases, such as cancer. Proteomic characterization of chromatin and de novo identification of chromatin interactors could, thus, reveal important and perhaps unexpected players implicated in human physiology and disease. Recently, intensive research efforts have focused on developing strategies to characterize the chromatome composition. In this review, we provide an overview of the dynamic composition of the chromatome, highlight the importance of its alterations as a driving force in human disease (and particularly in cancer), and discuss the different approaches to systematically characterize the chromatin-bound proteome in a global manner. 相似文献
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《Journal of Plant Interactions》2013,8(3):271-282
Coastal-ridge plains are progradational landforms composed of elevated ridges and low-lying swales. The transitions between ridges and swales are steep, promoting dynamic shifts between xeric and mesic systems. Two understory plants that co-occur in ridge plains of North American mid-Atlantic maritime forests are Sabal minor and Ilex vomitoria. As coastal-ridge plains foster varying amounts of surface and sub-surface water driven largely by topography, the purpose of this study was to evaluate plant–water relations and chlorophyll a fluorescence in these two species. Ridge plants had lower leaf- and xylem-water potentials, lower osmotic potential (I. vomitoria), and lower symplastic water content (S. minor). Although there were no differences in potential- and effective-quantum yields, there were decreases in fluorescence performance index for ridge I. vomitoria and swale S. minor. While the data support potential water-stress conditions in ridge plants of both species, the data also suggest that I. vomitoria and S. minor use different physiological processes to tolerate hydrologically dynamic ridge–swale maritime forests. 相似文献
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Abstract We report the identification of an open reading frame in a serogroup B isolate of Neisseria meningitidis that exhibits high nucleotide and predicted amino acid identity with the fpg gene of Escherichia coli , and its product, formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase), a DNA repair enzyme. We further show that the meningococcal fpg is co-transcribed with nlaA , encoding a lysophosphatidic acid acyltransferase, and suggest that the DNA repair enzyme may be involved in the regulation of nlaA or its gene product. 相似文献